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NS121 Human Biology: Selected Topics in Medicine
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OCTOBER 2008 ASSIGNMENTS

Check the web site each week as the assignments page is updated.
PLEASE WORD-PROCESS ALL WRITTEN WORK YOU HAND IN.

DATE DUE ASSIGNMENT

Oct 1
Wednesday

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Assignment # 12
TA JAMIE MOODY WILL BE IN CSC 333 FROM 7:00 PM TO 10:00 PM,
SO PLAN TO START WORKING ON YOUR ARTICLE REVIEW IN A NICE SUPPORTIVE, QUIET ATMOSPHERE.

MAKE ARRANGEMENTS WITH A FRIEND TO GO TOGETHER TO USE THESTUDY SPACE. SPREAD THE WORD THAT THIS IS A HELPFUL PLACE TO WORK.

CHECK OUT THE RUBRIC FOR WRITING A GOOD ANALYSIS OF A PRIMARY ARTICLE

 

Class Activity

  • Guest: Aaron Buchsbaum. Hampshire graduate (in 2005 and former NS121 TA). Aaron as been working as Senior Research Technician at the Tufts University Lipid Metabolism Lab Human Nutrition Lab on Aging and also as a teaching assistant in the Tufts Community Health Program.

    He has also had several other interesting jobs since leaving Hampshire and in two weeks will embark on a major endeavor as a Peace Corps volunteer in Berkina Faso.

  • A bit more work with data and conclusions in Article #1.

Oct 3
Friday

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Assignment # 13
 

Bring in drafts of sections of the report that you want help with. Have questions ready to ask us.

REMEMBER THAT TA SOPHIYA KARKI IS AVAILABLE TO HELP YOU IN COLE SCIENCE CENTER ON SATURDAY AND SUNDAY NIGHTS. SHE WORKS AT THE MONITOR DESK ON THE SECOND FLOOR (THE END OF THE BUILDING NEAR THE LIBRARY.

Class Activity

  • Sophiya Karki will tell you about what Hill et al. meant when they were talking about gene expression.
  • Q&A about any other questions you have that will help you write your review. Don't be embarrassed to ask! Everyone has questions, they just don't always feel comfortable asking in a big group. Start a trend!
  • .Merle's helpful hints for using citations and finding your own voice in your analytical writing.

Oct 6
Monday

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Assignment # 14
THIS IS ONE OF THE MAJOR PIECES OF WORK DUE THIS SEMESTER.

 
  • Turn in your full analysis of Article #1. You have been writing sections of this analysis all along, so it shouldn't be hard to put them together as a single analysis. Use feedback we have given you on sections you turned in already in revising and constructing your final analysis and consult the handout we gave you for the first group activity on primary articles. Address all four sections: Introduction, Methods (Experimental Design), Results (use graphs and tables), and Conclusions.

    Follow the handout we handed out to structure the group work. Also, consult these links about writing about experimental design and data analysis.
    Merle's low key intro to data analysis
  • Yale Statistics Couse handout on Experimental Design
    Univ. of Cal. at Davis handout on Experimental Design

    Write what you understand about the experimental design. Indicate what you think their reasons were for setting up the study as they did. Did they use controls? What were they and what did they control for? What difference might it have made to their conclusions if they hadn't used those controls?

    Always, if you are confused about something or aren't certain you understand it fully, WRITE THOSE questions and explain what it is that you are confused about. That is a valid part of your report and one we are happy to see.

  • HEADS UP: Mid-semester portfolios are due on Wednesday. Check out the guidelines about how to construct your portfolio and write your self evaluation.

    This is something you could start doing if you're going home for fall break. It's a way to show friends and family what you've been doing when you don't have mid semester grades to report (as some of your friends will). You'll be surprised at how impressive it will look!

Class Activities

  • Review of answers to previous study questions and some Q&A about other topics addressed in the work you've been doing
  • Review Study Question responses for Study questions 1 and 2 as well as any left over questions from Article #1.

Oct 8
Wednesday

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  • Assignment # 15
    MID SEMESTER PORTFOLIOS AND SELF EVALUATIONS ARE DUE TODAY
    It is imperative that you hand these in before 2 pm today.


 
  • Read Chapter XX in Chiras and complete these Study Questions.

    Read the chapter through once before trying to answer the questions. If you come to parts that really confuse you, just keep reading and make a note to us about what sections you'd like to understand better.

  • Turn in portfolios with self evaluations to us in class, and also put your self evaluation on The Hub. (Everyone should do this, NOT just first semester Hampshire students)

    This is a fun (but important) assignment that just involves putting together all the work you've already done. You probably got a message from the advising office telling you to enter your mid term self evaluation on TheHub.

    In a 3 ring notebook or in a very well organized folder, put together all the work you have completed so far. When it is all together, read through it and only THEN write your self evaluation.

    The self evaluation is an assessment of what progress you have made on each of the five learning goals we are focusing on in this class. Note also which of the goals you feel you need to work most on for the rest of the semester.

    This link will tell you how to construct your MID SEMESTER PORTFOLIO and how to write a self evaluation.

    The good news is, once you write the self evaluation (and enter it on TheHub), it's in our laps and we have to write your mid-semester evals. This is something we do carefully so we can advisee each of you about your progress and what you should be focusing on next (in terms of skills developement) for the remainder of the semester.

Class Activities

  • Start Case B

Oct 10
Friday

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Assignment # 16  
  • NEXT WEDNESDAY, the first draft of your analysis of Article # 2 is due. This is a PRIMARY article you found on a topic of interest to you.. Use the analysis skills you learned from working with Article #1). You will have a chance to revise this, so don't worry if you think it isn't perfect.

    This details here are just to remind you to work on this before you leave for break. Work on it in the morning when we usually have class, and you'll at least have a rough draft to start with.

    In the top right corner, label this as Article #2, version 1.

    See Helaine Selin for help if you're not sure you have the right kind of article or if you're having trouble finding the one you want. Her contact info is on the first page of this web site. Click on Info under her name.
  • Prepare two copies of a summary of one of the primary articles you listed above (one copy for us and one for another student to read). Also hand in a copy of the article itself (your partner may also want to see a copy of the article).
  • Use the computer search techniques Helaine taught you or go to the second floor stacks in the library and thumb through recent scientific journals.
  • Answer these questions about that article.
  • As you write this summary, practice the following two strategies for writing critical summaries:
    • State clearly the question(s) being addressed by the investigators who conducted this study. They may have stated it as a hypothesis to be tested, and you may also state it in this way.
    • Ask questions about how the author knows what she/he is saying (what evidence was presented, what references were given). If you had a chance to talk with the author, what would you ask? Attach a copy of the article to the summary you give to us.
    • Remember to tell us about the RESULTS, not just the conclusions.

Class Activities

  • We will not have a regular class today, so you will have time to follow up some of the background questions that came up for you on Case B. When you get back from Fall Break, you'll be introduced to a new computer program called Rashi. Using Rashi, you will be able to interview the patient and her mother, ask for physical exam results and lab test results, and organize and share the information you collect.

    This program is being developed in collaboration with computer scientists at the Computer Science department at UMass. Hampshire students and faculty have been involved with the development of this program and you will be testing a new feature and after completing the case will be asked to evaluate the program and make suggestions for improving it.

  • You should also have a copy of your editing partner's review of Article #2 and should be giving that a careful reading using the guidelines we handed out so you can provide feedback that will help the writer improve her or his next draft.

Oct 13
Monday

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Fall Break  
  • No assignments due today.

Class Activities

  • NO CLASS TODAY

Oct 15
Wednesday

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Assignment # 17

 
  • THE FIRST DRAFT OF YOUR REVIEW OF ARTICLE 2 IS DUE TODAY.
    Look at the assignment block for last Friday for guilelines in writing it.

    Remember to bring 2 copies of your review and one hard copy of the article itself to class. You'll switch your reviews with another student and you will provide each other with feedback that will help both of you revise it for Friday.

  • Bring the information you started to collect as well as quesetions about the patient in Case B.

Class Activities

  • Begin Rashi in analysis of Case B
  • Exchange the first draft of your Article #2 review with your editing partner

Oct 17
Friday

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Faculty turn in mid-semester evaluations today.

Assignment # 18    
  • .Read Chapter 6, The Circulatory System, in Chiras and write answers (to turn in today) to these Study Questions.
  • Return the edited version of the analysis of Article #2 to your editing partner. For guidance in giving helpful feedback, consult these peer editing guidelines.

Class Activities

  • Case B

Oct 20
Monday

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Assignment # 19  
  • Turn in revised analysis of Article #2. . For guidance, review this rubric for writing article analyses. Don't expect to achieve the highest levels of analysis the first time, but work towards those goals

    This should be a substantial revision of your initial draft that will demonstrate progress you have made in understanding how to assess the quality of the experimental design and will show your progress in understanding how to talk about the results. Use feedback given by your readers, but try to go beyond merely making "corrections." Show what you have learned about writing an analysis.

    Include in this analysis at least 2 questions you have about things you don't fully understand.

    With your revision, include copies of your first draft with the readers' comments and also a copy of the article. Be sure to label your new draft as "Article # 2, version 2."

Class Activities

  • Rashi Case B
    • Focus on group work to complete the case--use all your team roles to really refine your work.
    • Fill in your rationales, references, explanations, questions, etc. in the Inquiry Notebook
    • Use the Report Generator on Rashi to Save your report as html on the computer desktop.
      • Cut and paste it into a Word file and Save the File as
        YourFirstAndLastName-CaseC08
      • E mail the file to mbruno@hampshire.edu,fgiahi@hampshire.edu

  • Review of rubrics for writing case reports and primary article analyses.
  • Sample case report demo

Oct 22
Wednesday

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Assignment # 20
JAMIE HAS OFFICE HOURS IN 333 FROM 7-10 PM. MANY OF YOU ARE FEELING THE SQUEEZE OF LOTS OF WORK DUE. YOUR TA'S ARE THERE TO HELP. LEARN TO USE THEM. IT'S AN IMPORTANT SKILL.

 

Class Activities

  • Concluding discussion of Case B and of the Rashi program
  • Fill out team feedback forms
  • We'll go over some biology that you might have questions about to help you write background sections of your case report. Come in with questions. We'll go over the past two Study Question answers as well.

Oct 24
Friday

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Assignment # 21
Family and Friends Weekend. Many activities are planned for Family and Friends weekend. Join in when you can, even if you don't have family and friends who were able to attend.
 
  • CASE B REPORT IS DUE TODAY

    Prep for Case Report.
    This is going to be your major case report, so we expect it will be your very best effort!

    Start with the first section--what we called the differential diagnosis. This is where you list all the conditions you considered and explain the reasoning you used in considering them. Tell us something about each condition, not just its name. Then for each one that you are either rejecting or making less likely, tell us what evidence led you to making that decision. If there were test results, explain how those results influenced your decision (use actual numbers).

    Don't just rely on one piece of information
    or say general things like "the symptoms didn't fit it well." Show off what you learned! That's the only way we'll know. Remember to insert citations to show where you learned what you know.

    Look now at the rubric we use to assess case reports so you can be sure to progress in analytical skills beyond what you demonstrated in your last case report--and so you can ask for clarification of anything you see in the rubric that isn't clear.
    You might also look at the sample case reports two students wrote about another case.

    USE THESE SUGGESTIONS FOR HOW TO STRUCTURE YOUR REPORT

  • PART I: DIFFERENTIAL DIAGNOSIS

    Start with a statement of the case and your team's final recommendation. Then step back and tell us ALL the intial diagnoses you considered and why. Then pick the top 4-5 and explain in detail and with actual data how you eliminated some or put them down farther on your list of possibilities.

    Include in this discussion what amounts to about 2-3 pages that show how much you learned about one of the biological systems involved and how that knowlege helps you understand how test results reveal something about that system.

  • Part II: DIAGNOSIS

    This should be quite substantial and explain (using actual data from patient history, physical exam, and lab tests) how you came to this decision and if any of the data confirmed your diagnosis.

    We'd like to see a substantial section that shows you understand the biology about what caused this condition, how the body reacted to it in ways that led to the symptoms and signs, and what the test results revealed about the biology. Be very specific (never say "the body reacted to...." tell us what organ, tissues, cells, etc. did the reacting and how they worked).

  • PART III: RECOMMENDATIONS

    What treatment(s) do you recommend? What outcome do you expect from the treatment? How would you explain to the parents (who want to understand what is going on) exactly what is going on and why did this happen to Bill and not his sister? Should they be concerned about anything or watch for any symptoms in either child in the future? When will you see the patient again, and what will you look for and what do you hope for?

  • PART IV: REFERENCES

    Include all through your report citations that show where you got your information. At the end, include a full bibliography in standard format. Check this link for suggestions about VOICE, PROPER CITATION FORMS, AND paperhinPLAGIARISM and this one for help with BIBLIOGRAPHIES AND FOOTNOTES.

    The information on both these links will help with your article reviews and final paper as well.

    You learned a lot from your first case report about how to write more detailed, analytical reports that demonstrate all the work you and your team did on the differential diagnosis and final diagnosis.

    Consult the rubric for writing case reports to help you.

    In this report, we'll be expecting you to include a good deal more content (understanding of how the biological systems you are mentioning work) and an application of that content.

    Here's an example of what we mean by application:
    If you are talking about a particular blood test or physical exam result, explain the biology underlying it. So if you asked for a FSH test, what hypothesis did that help you either eliminate or continue to pursue, how is that test done, what do the results tell you about the normal or abnormal function of the ovaries or pituitary gland or hypothalamus, etc.?

    In other words, pull all the pieces (symptoms, history, lab results, details of structure and function of the organ or system involved) together and try to make sense out of it. Use your textbook for a lot of this information, and remember to cite it appropriately.


  • LEARNING GOAL: REMINDER THAT YOUR PROGRESS IN WRITING CASE REPORTS IS ONE OF THE THINGS WE'LL LOOK AT IN ASSESSING PROGRESS YOU'VE MADE ON FOUR OF THE LEARNING GOALS:

    1. Learn to read and interpret intellectual or artistic works. (how you use medical and biology texts, professional level web sites, other sources in solving the case )

    2. Write critically and analytically.
    (check the rubric for details of what we'll look for in all aspects of this writing)


    3. Understand quantitative methods of analysis
    (use specific test results thoughtfully and carefully)


    4. Conceive and complete project-based work
    (your report should demonstrate clearly the approach you and your team took to solving the case and how you found, organized, and analyzed information)

Class Activities

  • Begin Case C (another Rashi case). For this case, we won't require the kind of long narrative report you did for the first two cases (you have enough on your hands!). Instead, we will have you turn in the information on your Report Editor (Rashi tool). So, every time you enter something into your Inquiry Notebook, be sure to fill in the details, rationale, etc. You can do that in class or later, but do it and it will then suffice to show all the work you did.

    That also means putting information (like biology background) into the Inquiry Notebook. That can't be done automatically--you'll have to type it in. But once you do it, it will appear in your report automoatically.

    REMEMBER TO ENTER ALL BIBLIOGRAPHIC SOURCE MATERIAL INTO YOUR RASHI FILE!

Oct 27
Monday

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Assignment # 22  
  • Write the first draft of an analysis of Article #3. This should be a primary article that you found as a possible resource for your final paper. Bring two copies of your analysis and a copy of the article itself to class.

    Label your review Article #3, version 1.

Class Activities

  • Switch article reviews with your editing partner. Remember to do this at the start of class.
  • Case C

Oct 29
Wednesday

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Assignment # 23
January Term registration begins tomorrow

 
  • Comment on your editing partner's Article 3 review. Provide feedback to help their revision be more analytical.

  • Final paper topic. Write 3 paragraphs (about 2-3 pages):

    • This is what I'm interested in and why it is interesting to me.
    • Here are some of the questions I have about this topic.
    • Of those questions, the one I'm most interest in pursuing in depth is...
    • List at least 3 citations you have found on this topic (at least 2 should be primary articles, the others can be review articles, web sites, texts, etc.) You may use articles you've already written about in your analytical summaries.

Class Activities

  • Return edited Article 3 review to your editing partner.
  • Case C

Oct 31
Friday

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Assignment # 24
Div II and III preliminary request period ends
 
  • Next Friday several draft sections are due on your final paper. If you want to give us any of those earlier, mention that when you hand them in and we'll try to get them back soon.

  • Use the Wednesday night study time and Saturday evening and Sunday afternoon with your TA's. CSC 333 is a nice place to work at night.

Class Activities

  • Case C.
    1. Complete all the sections of your case report--we'll go around and help with last minute questions.
    2. Save Your Final Report of Rashi Report Editor on the desktop as an html file.
    3.Cut and paste it into a Word file and Save the File as
    4. YourFirstAndLastName-CaseC08
    5. E mail the file to mbruno@hampshire.edu,fgiahi@hampshire.edu

  • Discussion with Rashi research team

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